Riluzole suppresses experimental autoimmune encephalomyelitis: Implications for the treatment of multiple sclerosis

Yossi Gilgun-Sherki, Hana Panet, Eldad Melamed, Daniel Offen*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Recent studies suggest that glutamate neurotoxicity is involved in the pathogenesis of multiple sclerosis (MS), and that treatment with glutamate receptor (AMPA/kainate) antagonists inhibits experimental autoimmune encephalomyelitis (EAE), the conventional model of MS. Therefore, we examined whether riluzole, an inhibitor of glutamate transmission, affects the pathogenesis and clinical features of MS-like disease in myelin oligodendrocyte glycoprotein (MOG)-induced EAE in mice. Here we report that riluzole (10 mg/kg×2/day, i.p.), administered before and even after the appearance of clinical symptoms, dramatically reduced the clinical severity of MOG-induced EAE, while all the MOG-immunized control mice developed significant clinical manifestations. Moreover, the riluzole-treated mice demonstrated only mild focal inflammation, and less demyelination, compared to MOG-treated mice, using histological methods. Furthermore, riluzole markedly reduced axonal disruption, as assessed by Bielshowesky's silver staining and by antibodies against non-phosphorylated neurofilaments (SMI-32). No difference was detected in the immune system potency, as T-cell proliferative responses to MOG were similar in both groups. In conclusion, our study demonstrates, for the first time, that riluzole can reduce inflammation, demyelination and axonal damage in the CNS and attenuate the clinical severity of MOG-induced EAE. These results suggest that riluzole, a drug used in amyotrophic lateral sclerosis (ALS), might be beneficial for the treatment of MS.

Original languageEnglish
Pages (from-to)196-204
Number of pages9
JournalBrain Research
Issue number2
StatePublished - 7 Nov 2003


FundersFunder number
National Parkinson Foundation
Tel Aviv University
Ministry of Health, State of Israel


    • Experimental autoimmune encephalomyelitis
    • Glutamate
    • Multiple sclerosis
    • Myelin oligodendrocyte glycoprotein
    • Riluzole


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