Right prefrontal slow repetitive transcranial magnetic stimulation in schizophrenia: A double-blind sham-controlled pilot study

Ehud Klein, Yael Kolsky, Michael Puyerovsky, Danny Koren, Andrei Chistyakov, Moshe Feinsod

Research output: Contribution to journalArticlepeer-review

Abstract

Background: The aim of this study was to extend our previous work on the therapeutic efficacy of repetitive transcranial magnetic stimulation (rTMS) in major depression to patients with schizophrenia. Methods: Thirty-five inpatients with schizophrenia were randomly assigned to either right prefrontal rTMS or sham treatment and were rated before and after treatment for positive, negative, and depressive symptoms. Results: Thirty-one subjects (rTMS = 16, sham = 15) completed a 2-week treatment protocol. No serious adverse effects were reported; however, rTMS was not superior to sham treatment on any of the clinical ratings. Conclusions: In contrast to our previous positive findings in major depression, right prefrontal slow rTMS does not appear to have a beneficial effect for actively psychotic patients with schizophrenia.

Original languageEnglish
Pages (from-to)1451-1454
Number of pages4
JournalBiological Psychiatry
Volume46
Issue number10
DOIs
StatePublished - 15 Nov 1999
Externally publishedYes

Keywords

  • Prefrontal cortex
  • Rating scales
  • Schizophrenia
  • Transcranial magnetic stimulation

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