Rifampin augments cytokine-induced nitric oxide production in human alveolar epithelial cells

Yael Yuhas, Eva Berent, Hila Ovadiah, Inbar Azoulay, Shai Ashkenazi

Research output: Contribution to journalArticlepeer-review

Abstract

Rifampin increased nitric oxide production and inducible nitric oxide synthase expression in alveolar cells stimulated with cytokines. Nitric oxide concentrations after induction with cytokines, cytokines with 10 μg/ml rifampin, and cytokines with 50 μg/ml rifampin were 3.2, 4.5, and 8.8 μM, respectively (P < 0.02 versus cytokines alone). This indicates that rifampin modulates the immune response.

Original languageEnglish
Pages (from-to)396-398
Number of pages3
JournalAntimicrobial Agents and Chemotherapy
Volume50
Issue number1
DOIs
StatePublished - Jan 2006

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