Ribosomes are optimized for autocatalytic production

Shlomi Reuveni; Måns Ehrenberg; Johan Paulsson

doi:10.1038/nature22998

Ribosomes are optimized for autocatalytic production

Shlomi Reuveni, Måns Ehrenberg, Johan Paulsson^*

^*Corresponding author for this work

Research output: Contribution to journal › Article › peer-review

53 Scopus citations

Abstract

Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. Here we demonstrate mathematically that many less well understood, larger-scale features of ribosomes - such as why a few ribosomal RNA molecules dominate the mass and why the ribosomal protein content is divided into 55-80 small, similarly sized segments - speed up their autocatalytic production.

Original language	English
Pages (from-to)	293-297
Number of pages	5
Journal	Nature
Volume	547
Issue number	7663
DOIs	https://doi.org/10.1038/nature22998
State	Published - 19 Jul 2017
Externally published	Yes

Funding

Funders	Funder number
NSF-DMS	PD127334
Wallenberg Foundation
National Institutes of Health
National Institute of General Medical Sciences	R01GM095784
James S. McDonnell Foundation
Horowitz Foundation for Social Policy	RGP0042
Vetenskapsrådet

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10.1038/nature22998

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Ribosomes are optimized for autocatalytic production

Abstract

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