Ribosomes are optimized for autocatalytic production

Shlomi Reuveni, Måns Ehrenberg, Johan Paulsson

Research output: Contribution to journalArticlepeer-review

Abstract

Many fine-scale features of ribosomes have been explained in terms of function, revealing a molecular machine that is optimized for error-correction, speed and control. Here we demonstrate mathematically that many less well understood, larger-scale features of ribosomes - such as why a few ribosomal RNA molecules dominate the mass and why the ribosomal protein content is divided into 55-80 small, similarly sized segments - speed up their autocatalytic production.

Original languageEnglish
Pages (from-to)293-297
Number of pages5
JournalNature
Volume547
Issue number7663
DOIs
StatePublished - 19 Jul 2017
Externally publishedYes

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