Ribosomal RNA cistron topography in Escherichia coli

M. Osenholts*, S. A. Yankofsky, E. Segal

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


Reported here are experiments showing that the multiple cistrons coding for the 23-S component of ribosomal RNA in Escherichia coli are not arranged as a single, contiguous block of genes. Instead, it is probable that a gene for 16-S ribosomal RNA is in close physical proximity to every individual 23-S ribosomal RNA locus. Moreover, interspersed between such 23-16-S gene pairs are regions of "spacer" DNA which are at least 2000 deoxyribonucleotide residues long. The possible significance of these findings is discussed.

Original languageEnglish
Pages (from-to)88-100
Number of pages13
JournalBBA Section Nucleic Acids And Protein Synthesis
Issue number1
StatePublished - 21 Apr 1973


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