Rheumatoid factor-associated high-molecular-weight complexes in the menstrual and amniotic fluids

Reuvit Halperin, David Schneider, Perry F. Kraicer, Eran Hadas

Research output: Contribution to journalArticlepeer-review

Abstract

We have previously described the identification of the human decidua-associated protein hDP200 as a rheumatoid factor [1], Assuming that rheumatoid factor binds to Fc of immunoglobulins, the existence of high-molecular-weight complexes was studie in decidual extract, pooled uterine fluid from proliferative and early secretory phase, menstrual fluid and amniotic fluid. High-molecular-weight complexes containing hDP200 and other immunoglobulins were found only in menstrual and amniotic fluids and not in decidual extract or uterine fluid. It is possible that complexing of the immunoglobulins by hDP200 serves as one of the mechanisms that ensure suppression of the immune response to fetal antigens.

Original languageEnglish
Pages (from-to)220-223
Number of pages4
JournalGynecologic and Obstetric Investigation
Volume41
Issue number3
DOIs
StatePublished - 1 Mar 1996
Externally publishedYes

Keywords

  • Amniotic fluid
  • High-molecular-weight complexes
  • Menstrual fluid
  • Rheumatoid factor
  • hDP200

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