Rheumatoid arthritis exacerbation caused by exogenous interleukin-12

Elena Peeva, Ari D. Fishman, Gisele Goddard, Scott Wadler, Peter Barland*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

24 Scopus citations


Interleukin-12 (IL-12) is a pleiotropic cytokine with proinflammatory, immunoregulatory, antitumor, and antimetastatic properties. It plays a crucial role in the development of the Th1 response and subsequent interferon-γ, production and enhancement of cell-mediated cytotoxicity. Recently, IL-12 has been used as an experimental therapy for cancer. Given the multiple immunomodulatory properties of IL-12, there are potential concerns associated with its clinical use. Of special interest are the possible side effects of IL-12 therapy in patients with autoimmune diseases, especially those that are T cell mediated, such as rheumatoid arthritis (RA). We present a case of severe RA exacerbation caused by treatment with IL-12 for metastatic cervical cancer. This is the first reported case of RA flare caused by exogenous IL-12.

Original languageEnglish
Pages (from-to)461-463
Number of pages3
JournalArthritis and Rheumatism
Issue number2
StatePublished - Feb 2000
Externally publishedYes


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