TY - JOUR
T1 - Rheumatoid arthritis exacerbation caused by exogenous interleukin-12
AU - Peeva, Elena
AU - Fishman, Ari D.
AU - Goddard, Gisele
AU - Wadler, Scott
AU - Barland, Peter
PY - 2000/2
Y1 - 2000/2
N2 - Interleukin-12 (IL-12) is a pleiotropic cytokine with proinflammatory, immunoregulatory, antitumor, and antimetastatic properties. It plays a crucial role in the development of the Th1 response and subsequent interferon-γ, production and enhancement of cell-mediated cytotoxicity. Recently, IL-12 has been used as an experimental therapy for cancer. Given the multiple immunomodulatory properties of IL-12, there are potential concerns associated with its clinical use. Of special interest are the possible side effects of IL-12 therapy in patients with autoimmune diseases, especially those that are T cell mediated, such as rheumatoid arthritis (RA). We present a case of severe RA exacerbation caused by treatment with IL-12 for metastatic cervical cancer. This is the first reported case of RA flare caused by exogenous IL-12.
AB - Interleukin-12 (IL-12) is a pleiotropic cytokine with proinflammatory, immunoregulatory, antitumor, and antimetastatic properties. It plays a crucial role in the development of the Th1 response and subsequent interferon-γ, production and enhancement of cell-mediated cytotoxicity. Recently, IL-12 has been used as an experimental therapy for cancer. Given the multiple immunomodulatory properties of IL-12, there are potential concerns associated with its clinical use. Of special interest are the possible side effects of IL-12 therapy in patients with autoimmune diseases, especially those that are T cell mediated, such as rheumatoid arthritis (RA). We present a case of severe RA exacerbation caused by treatment with IL-12 for metastatic cervical cancer. This is the first reported case of RA flare caused by exogenous IL-12.
UR - http://www.scopus.com/inward/record.url?scp=0034094439&partnerID=8YFLogxK
U2 - 10.1002/1529-0131(200002)43:2<461::AID-ANR29>3.0.CO;2-7
DO - 10.1002/1529-0131(200002)43:2<461::AID-ANR29>3.0.CO;2-7
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C2 - 10693889
AN - SCOPUS:0034094439
SN - 0004-3591
VL - 43
SP - 461
EP - 463
JO - Arthritis and Rheumatism
JF - Arthritis and Rheumatism
IS - 2
ER -
