Rheumatoid Arthritis and Infections: More Than an Association?

Hussein Mahajna*, Naim Mahroum, Howard Amital

*Corresponding author for this work

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review


Rheumatoid arthritis is a systemic disease manifested mainly as erosive arthritis. The aetiology of the disease is not fully understood, and it is believed to be multifactorial. Studies suggest that both environmental and genetic factors take part in the pathogenesis of rheumatoid arthritis. Several infectious agents have been associated with rheumatoid arthritis. The suggested pathway of pathogenesis is the production of citrullination enzymes, which modifies self-antigens to unrecognized proteins that induce an immune reaction. In this chapter, we review the current data about the association between rheumatoid arthritis and different infectious agents.

Original languageEnglish
Title of host publicationInfection and Autoimmunity
PublisherElsevier Inc.
Number of pages6
ISBN (Print)9780444632692
StatePublished - 1 Jan 2015


  • Anticycle citrullinated peptides
  • Infections
  • Rheumatoid arthritis


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