TY - CHAP
T1 - Rheumatoid Arthritis and Infections
T2 - More Than an Association?
AU - Mahajna, Hussein
AU - Mahroum, Naim
AU - Amital, Howard
N1 - Publisher Copyright:
© 2015 Elsevier B.V. All rights reserved.
PY - 2015/1/1
Y1 - 2015/1/1
N2 - Rheumatoid arthritis is a systemic disease manifested mainly as erosive arthritis. The aetiology of the disease is not fully understood, and it is believed to be multifactorial. Studies suggest that both environmental and genetic factors take part in the pathogenesis of rheumatoid arthritis. Several infectious agents have been associated with rheumatoid arthritis. The suggested pathway of pathogenesis is the production of citrullination enzymes, which modifies self-antigens to unrecognized proteins that induce an immune reaction. In this chapter, we review the current data about the association between rheumatoid arthritis and different infectious agents.
AB - Rheumatoid arthritis is a systemic disease manifested mainly as erosive arthritis. The aetiology of the disease is not fully understood, and it is believed to be multifactorial. Studies suggest that both environmental and genetic factors take part in the pathogenesis of rheumatoid arthritis. Several infectious agents have been associated with rheumatoid arthritis. The suggested pathway of pathogenesis is the production of citrullination enzymes, which modifies self-antigens to unrecognized proteins that induce an immune reaction. In this chapter, we review the current data about the association between rheumatoid arthritis and different infectious agents.
KW - Anticycle citrullinated peptides
KW - Infections
KW - Rheumatoid arthritis
UR - http://www.scopus.com/inward/record.url?scp=85072141283&partnerID=8YFLogxK
U2 - 10.1016/B978-0-444-63269-2.00065-9
DO - 10.1016/B978-0-444-63269-2.00065-9
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AN - SCOPUS:85072141283
SN - 9780444632692
SP - 729
EP - 734
BT - Infection and Autoimmunity
PB - Elsevier Inc.
ER -