Rheumatic manifestations and autoimmunity associated with COVID-19

Danielle Zemer Lev, Arad Dotan, Michael Ehrenfeld

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

A broad spectrum of complications following COVID-19 has been documented in adults, including the new onset of autoimmune-related manifestations and rheumatic diseases. Numerous case studies, reviews, and clinical trials have been published regarding the relationship between COVID-19 and the generation of autoantibodies that may cause rheumatic and autoimmune diseases. The currently suggested pathophysiology that leads to the new onset of such disorders may include well-established mechanisms, such as molecular mimicry and hyperstimulation of the immune system. The prevailing conditions documented following COVID-19 include, yet are not limited to, rheumatoid arthritis, myositis, antiphospholipid antibodies, ITP, and thyroid dysfunction. This chapter will summarize the current documentation of the broad-spectrum rheumatic diseases and autoimmune manifestations mediated by a SARS-CoV-2 infection.

Original languageEnglish
Title of host publicationAutoimmunity, COVID-19, Post-COVID19 Syndrome and COVID-19 Vaccination
PublisherElsevier
Pages437-449
Number of pages13
ISBN (Electronic)9780443185663
ISBN (Print)9780443185670
DOIs
StatePublished - 1 Jan 2022

Keywords

  • Antiphospholipid antibodies
  • Autoimmune manifestations
  • Autoimmunity
  • COVID-19
  • Guillain Barre syndrome
  • Rheumatic disease
  • Rheumatoid arthritis
  • SARS-CoV-2

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