Rhabdomyolysis associated with Clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes

Wladimir Koren; Ella Koren; Nitza Nacasch; Michael Ehrenfeld; Hanan Gur

Rhabdomyolysis associated with Clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes

Wladimir Koren^*, Ella Koren, Nitza Nacasch, Michael Ehrenfeld, Hanan Gur

^*Corresponding author for this work

Clinical Departments

Research output: Contribution to journal › Article › peer-review

Abstract

A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia. No risk factors for rhabdomyolysis were found, but the calcium-dependent potassium efflux, normally responsible for membrane hyperpolarization and muscle refractoriness, was severely decreased in the patient's red blood cells. Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K⁺ channels.

Original language	English
Pages (from-to)	262-264
Number of pages	3
Journal	Clinical Neuropharmacology
Volume	21
Issue number	4
State	Published - Jul 1998

Keywords

Calcium-dependent potassium channels
Clozapine
Rhabdomyolysis

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title = "Rhabdomyolysis associated with Clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes",

abstract = "A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia. No risk factors for rhabdomyolysis were found, but the calcium-dependent potassium efflux, normally responsible for membrane hyperpolarization and muscle refractoriness, was severely decreased in the patient's red blood cells. Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.",

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author = "Wladimir Koren and Ella Koren and Nitza Nacasch and Michael Ehrenfeld and Hanan Gur",

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journal = "Clinical Neuropharmacology",

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T1 - Rhabdomyolysis associated with Clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes

AU - Koren, Wladimir

AU - Koren, Ella

AU - Nacasch, Nitza

AU - Ehrenfeld, Michael

AU - Gur, Hanan

PY - 1998/7

Y1 - 1998/7

N2 - A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia. No risk factors for rhabdomyolysis were found, but the calcium-dependent potassium efflux, normally responsible for membrane hyperpolarization and muscle refractoriness, was severely decreased in the patient's red blood cells. Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.

AB - A 21-year-old patient developed rhabdomyolysis during his nineteenth week of treatment with clozapine for drug-resistant schizophrenia. No risk factors for rhabdomyolysis were found, but the calcium-dependent potassium efflux, normally responsible for membrane hyperpolarization and muscle refractoriness, was severely decreased in the patient's red blood cells. Clozapine is speculated to cause rhabdomyolysis in patients with defective calcium-activated K+ channels.

KW - Calcium-dependent potassium channels

KW - Clozapine

KW - Rhabdomyolysis

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SN - 0362-5664

VL - 21

SP - 262

EP - 264

JO - Clinical Neuropharmacology

JF - Clinical Neuropharmacology

IS - 4

ER -

Rhabdomyolysis associated with Clozapine treatment in a patient with decreased calcium-dependent potassium permeability of cell membranes

Abstract

Keywords

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