Review on experiment-based two- and three-dimensional models for wound healing

Daphne Weihs, Amit Gefen, Fred J. Vermolen*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review


Traumatic and chronic wounds are a considerable medical challenge that affects many populations and their treatment is a monetary and timeconsuming burden in an ageing society to the medical systems. Because wounds are very common and their treatment is so costly, approaches to reveal the responses of a specific wound type to different medical procedures and treatments could accelerate healing and reduce patient suffering. The effects of treatments can be forecast using mathematical modelling that has the predictive power to quantify the effects of induced changes to the wound-healing process. Wound healing involves a diverse and complex combination of biophysical and biomechanical processes.We reviewawide variety of contemporary approaches of mathematical modelling of gap closure and wound-healing-related processes, such as angiogenesis. We provide examples of the understanding and insights that may be garnered using those models, and how those relate to experimental evidence. Mathematical modellingbased simulations can provide an important visualization tool that can be used for illustrational purposes for physicians, patients and researchers.

Original languageEnglish
JournalInterface Focus
Issue number5
StatePublished - 6 Oct 2016


  • Angiogenesis
  • Cell deformation
  • Cell migration
  • Cellular automata models
  • Partial differential equations
  • Particle methods


Dive into the research topics of 'Review on experiment-based two- and three-dimensional models for wound healing'. Together they form a unique fingerprint.

Cite this