Review: Clinical and laboratory approach to the management of neutrophil dysfunction

B. Wolach, R. L. Baehner, L. A. Boxer

Research output: Contribution to journalReview articlepeer-review

Abstract

Disorders of neutrophil function can arise from abnormalities in the humoral signal mechanisms, or from defects in the sensory, motile or bactericidal responses of the cell, or from a combination of these functions, and should be discussed with emphasis on the molecular pathogenesis. Thus, normal neutrophils are equipped with antioxidant systems offering protection to organelles and membranous structures, and at the same time they are able to contain H2O2 and other oxidants within phagosomes for effective killing of microbes. The following clinical conditions associated with neutrophil dysfunction are discussed: defects of signal mechanism, sensory and motile response of phagocyte cells, disorders of chemotaxis, recognitions and ingestion disorders, nonoxidative and oxidative bactericidial mechanisms of phagocyte cells, myeloperoxidase deficiency, and disorders of oxidant removal.

Original languageEnglish
Pages (from-to)897-916
Number of pages20
JournalIsrael Journal of Medical Sciences
Volume18
Issue number9
StatePublished - 1982
Externally publishedYes

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