Reversible central nervous system dysfunction in folate deficiency

Eldad Melamed*, Avinoam Reches, Chaim Hershko

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


An epileptic patient on chronic anticonvulsant drug therapy is described, in whom anaemia and neurological abnormalities including progressive dementia, bilateral pyramidal tract signs, incontinence and ataxia developed. Vitamin B12 serum levels and absorption were normal, but serum folic acid levels were low. Both the neurological disturbances and anaemia resolved following oral folic acid administration. This sequence of events in our patient suggests a cause and effect relationship between the folate deficiency and the coexistent, transient neurological syndrome.

Original languageEnglish
Pages (from-to)93-98
Number of pages6
JournalJournal of the Neurological Sciences
Issue number1
StatePublished - May 1975
Externally publishedYes


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