Reversible busulfan-induced ovarian failure

Oded Shalev*, Galia Rahav, Ariel Milwidsky

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


A 26-yr-old woman with chronic myeloid leukemia developed busulfan-induced ovarian failure. The ovarian failure was manifested by amenorrhea and climacteric symptoms and was verified by elevated plasma levels of luteinizing and follicle-stimulating hormones concomitant with low 17β-estradiol levels. The amenorrhea proved to be reversible when, during hematological relapse one year later, the patient was found to be four months pregnant. The busulfan which she was receiving at that time was stopped and amniocentesis revealed a normal karyotype. The remainder of the pregnancy was unremarkable and was terminated by the normal delivery of a healthy child.

Original languageEnglish
Pages (from-to)239-242
Number of pages4
JournalEuropean Journal of Obstetrics, Gynecology and Reproductive Biology
Issue number3
StatePublished - Nov 1987
Externally publishedYes


  • Amenorrhea
  • Busulfan


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