TY - JOUR
T1 - Reversal of a neurologic paraneoplastic syndrome with octreotide (sandostatin) in a patient with glucagonoma
AU - Holmes, Alex
AU - Kilpatrick, Christine
AU - Proietto, Joseph
AU - Green, Michael D.
PY - 1991/10
Y1 - 1991/10
N2 - A 69-year-old woman with classic glucagonoma syndrome had associated progressive neurologic disease manifest as dementia, ataxia, optic atrophy, and lower limb weakness. Visual evoked responses (VERs) were absent bilaterally. After an attempt at resection was unsuccessful, therapy was started with somatostatin analogue (Sandostatin, SMS 201-995). Over the ensuing 3 months, there was a decrease in the plasma glucagon level, resolution of the rash, weight gain, reversal of the dementia, and an improvement in coordination and limb weakness. Subsequent VERs revealed bilateral delayed responses.
AB - A 69-year-old woman with classic glucagonoma syndrome had associated progressive neurologic disease manifest as dementia, ataxia, optic atrophy, and lower limb weakness. Visual evoked responses (VERs) were absent bilaterally. After an attempt at resection was unsuccessful, therapy was started with somatostatin analogue (Sandostatin, SMS 201-995). Over the ensuing 3 months, there was a decrease in the plasma glucagon level, resolution of the rash, weight gain, reversal of the dementia, and an improvement in coordination and limb weakness. Subsequent VERs revealed bilateral delayed responses.
UR - http://www.scopus.com/inward/record.url?scp=0026038858&partnerID=8YFLogxK
U2 - 10.1016/0002-9343(91)90164-S
DO - 10.1016/0002-9343(91)90164-S
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C2 - 1951389
AN - SCOPUS:0026038858
SN - 0002-9343
VL - 91
SP - 434
EP - 436
JO - American Journal of Medicine
JF - American Journal of Medicine
IS - 4
ER -