Return of symptoms after discontinuation of clomipramine in patients with obsessive-compulsive disorder

M. T. Pato, R. Zohar-Kadouch, J. Zohar, D. L. Murphy

Research output: Contribution to journalArticlepeer-review

246 Scopus citations

Abstract

To evaluate the need for maintenance drug therapy in patients with obsessive-compulsive disorder, the authors assessed 21 patients with obsessive-compulsive disorder who manifested sustained improvement during 5 to 27 months of clomipramine treatment and who agreed to participate in a double-blind discontinuation study. Of 18 patients who completed the study, 16 had substantial recurrence of obsessive-compulsive symptoms by the end of the 7-week placebo period. In addition, 11 had a significant increase in depressive symptoms. Treatment duration before discontinuation of clomipramine was not related to the frequency or severity of obsessive-compulsive or depressive symptom appearance. These findings suggest that prolonged drug treatment may be warranted for obsessive-compulsive disorder.

Original languageEnglish
Pages (from-to)1521-1525
Number of pages5
JournalAmerican Journal of Psychiatry
Volume145
Issue number12
DOIs
StatePublished - 1988
Externally publishedYes

Funding

FundersFunder number
Eunice Kennedy Shriver National Institute of Child Health and Human DevelopmentF35HD006930

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