Retinol-binding protein 4: A novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus

Shali Mazaki-Tovi, Roberto Romero, Edi Vaisbuch, Juan Pedro Kusanovic, Tinnakorn Chaiworapongsa, Sun Kwon Kim, Pooja Mittal, Zhong Dong, Percy Pacora, Lami Yeo, Sonia S. Hassan

Research output: Contribution to journalArticlepeer-review

Abstract

Objective: Adipokines (cytokines produced by adipose tissue) play a major role in the control of body weight and energy distribution. Retinol-binding protein 4 (RBP4), only recently recognized as an adipokine, has been proposed to modulate systemic insulin sensitivity. The goal of this study was to determine whether there is an association between maternal plasma RBP4 concentration and the birth of a large-for-gestational-age (LGA) newborn in women with and without gestational diabetes mellitus (GDM). Study design: This cross-sectional study included pregnant women at term in the following groups: 1) normal pregnancy with an appropriate-for-gestational-age (AGA) neonate (n=64); 2) normal pregnancy with an LGA neonate (n=44); 3) GDM with an AGA neonate (n=55); and 4) GDM with an LGA neonate (n=42). Maternal plasma RBP4 concentration was determined by ELISA. Parametric and non-parametric statistics were used for analyses. Results: 1) Patients with GDM, either with AGA or LGA neonates, had a higher median plasma concentration of RBP4 than normal pregnant women who delivered an AGA neonate (P=0.01 and P=0.008, respectively); 2) mothers without GDM but with LGA neonates had a higher median plasma concentration of RBP4 than those with normal pregnancy and AGA newborns (P=0.001); 3) these findings remained significant after adjusting for maternal age, body mass index and gestational age at blood sampling. Conclusion: GDM is characterized by alterations in maternal circulating RBP4 concentrations akin to those of Type 2 diabetes mellitus. RBP4 concentrations in maternal plasma may play a role in accelerated fetal growth in the absence of overt carbohydrate intolerance.

Original languageEnglish
Pages (from-to)147-155
Number of pages9
JournalJournal of Perinatal Medicine
Volume38
Issue number2
DOIs
StatePublished - 1 Mar 2010
Externally publishedYes

Keywords

  • Adipokine
  • Adipose tissue
  • Appropriate-for-gestational-age (AGA)
  • Body mass index (BMI)
  • Cytokine
  • Insulin resistance
  • Insulin sensitivity
  • Metabolism
  • Obesity
  • Overweight
  • Pregnancy

Fingerprint

Dive into the research topics of 'Retinol-binding protein 4: A novel adipokine implicated in the genesis of LGA in the absence of gestational diabetes mellitus'. Together they form a unique fingerprint.

Cite this