TY - JOUR
T1 - Retinal thickness in patients with mild cognitive impairment and Alzheimer's disease
AU - Kesler, Anat
AU - Vakhapova, Veronika
AU - Korczyn, Amos D.
AU - Naftaliev, Elvira
AU - Neudorfer, Meira
PY - 2011/9
Y1 - 2011/9
N2 - Objectives: Mild cognitive impairment (MCI) may represent a transition to early Alzheimer's disease (AD). The retinal nerve fiber layer (RNFL) is composed of axons originating in retinal ganglion cells that eventually form the optic nerves. Previous studies have shown that degenerative changes occur in optic nerve fibers and manifested as thinning of RNFL in patients with AD. The objective of this study was to assess the relationship between MCI, AD and loss of RNFL. Patients and methods: In this study, patients fulfilling diagnostic criteria for MCI (n = 24), AD (n = 30) and cognitively normal age-matched controls (n = 24) have undergone neuro-ophthalmologic and optical coherence tomography (OCT) examinations to measure RNFL thickness. Results: There was a significant decrease in RNFL thickness in both study groups (AD and MCI) compared to the control group, particularly in the inferior quadrants of the optic nerve head, while the superior quadrants were significantly thinner only in AD. Although AD patients may have more severe changes than MCI cases, the differences were statistically nonsignificant. Furthermore among AD patients, there was no relation to the severity of the dementia. Conclusions: Our data confirm the retinal involvement in AD, as reflected by loss of axons in the optic nerves.
AB - Objectives: Mild cognitive impairment (MCI) may represent a transition to early Alzheimer's disease (AD). The retinal nerve fiber layer (RNFL) is composed of axons originating in retinal ganglion cells that eventually form the optic nerves. Previous studies have shown that degenerative changes occur in optic nerve fibers and manifested as thinning of RNFL in patients with AD. The objective of this study was to assess the relationship between MCI, AD and loss of RNFL. Patients and methods: In this study, patients fulfilling diagnostic criteria for MCI (n = 24), AD (n = 30) and cognitively normal age-matched controls (n = 24) have undergone neuro-ophthalmologic and optical coherence tomography (OCT) examinations to measure RNFL thickness. Results: There was a significant decrease in RNFL thickness in both study groups (AD and MCI) compared to the control group, particularly in the inferior quadrants of the optic nerve head, while the superior quadrants were significantly thinner only in AD. Although AD patients may have more severe changes than MCI cases, the differences were statistically nonsignificant. Furthermore among AD patients, there was no relation to the severity of the dementia. Conclusions: Our data confirm the retinal involvement in AD, as reflected by loss of axons in the optic nerves.
KW - Alzheimer's disease
KW - Mild cognitive impairment
KW - Optical coherence tomography
KW - Retinal nerve fiber layer thickness
UR - http://www.scopus.com/inward/record.url?scp=79960563431&partnerID=8YFLogxK
U2 - 10.1016/j.clineuro.2011.02.014
DO - 10.1016/j.clineuro.2011.02.014
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AN - SCOPUS:79960563431
SN - 0303-8467
VL - 113
SP - 523
EP - 526
JO - Clinical Neurology and Neurosurgery
JF - Clinical Neurology and Neurosurgery
IS - 7
ER -