Retinal nerve fiber layer thinning in Parkinson disease

Rivka Inzelberg, Jose Antonio Ramirez, Puiu Nisipeanu, Avinoam Ophir

Research output: Contribution to journalArticlepeer-review

312 Scopus citations

Abstract

Retinal dopamine loss in Parkinson disease (PD) is reflected by visual neurophysiological dysfunction. We measured the thickness of the circumpapillary retinal nerve fiber layer (RNFL) in PD patients using optical coherence tomography. The thickness in the inferior quadrant of PD patients (147 ± 20 microns) was significantly thinner than that of controls (173 ± 12 microns; p = 0.002), while the inferotemporal area was the thinnest (146 ± 24 vs. 191 ± 21 microns; p = 0.0003). The results show significant loss of RNFL thickness in PD at specific sites.

Original languageEnglish
Pages (from-to)2793-2797
Number of pages5
JournalVision Research
Volume44
Issue number24
DOIs
StatePublished - Nov 2004
Externally publishedYes

Funding

FundersFunder number
Israel Ministry of Health, Chief Scientist

    Keywords

    • Optical coherence tomography
    • Parkinson
    • Retina
    • Retinal nerve fiber layer

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