TY - JOUR
T1 - Retinal Lineage Therapeutic Specific Effect of Human Orbital and Abdominal Adipose-Derived Mesenchymal Stem Cells
AU - Krief, Bryan
AU - Algor, Shira Weisthal
AU - Nakdimon, Itay
AU - Elhikis, Ayala
AU - Benhamou, Moshe
AU - Kadmon, Anouk Savir
AU - Keren, Shay
AU - Ohana, Oded
AU - Feldman, Ilan
AU - Cnaan, Ran Ben
AU - Leibovitch, Igal
AU - Loewenstein, Anat
AU - Barak, Adiel
AU - Barzelay, Aya
N1 - Publisher Copyright:
© 2021 Bryan Krief et al.
PY - 2021
Y1 - 2021
N2 - Retinal degenerative diseases are one of the main causes of complete blindness in aged population. In this study, we compared the therapeutic potential for retinal degeneration of human mesenchymal stem cells derived from abdominal subcutaneous fat (ABASCs) or from orbital fat (OASCs) due to their accessibility and mutual embryonic origin with retinal tissue, respectively. OASCs were found to protect RPE cells from cell death and were demonstrated to increase early RPE precursor markers, while ABASCs showed a raise in retinal precursor marker expression. Subretinal transplantation of OASCs in a mouse model of retinal degeneration led to restoration of the RPE layer while transplantation of ABASCs resulted in a significant restoration of the photoreceptor layer. Taken together, we demonstrated a lineage-specific therapeutic effect for either OASCs or ABASCs in retinal regeneration.
AB - Retinal degenerative diseases are one of the main causes of complete blindness in aged population. In this study, we compared the therapeutic potential for retinal degeneration of human mesenchymal stem cells derived from abdominal subcutaneous fat (ABASCs) or from orbital fat (OASCs) due to their accessibility and mutual embryonic origin with retinal tissue, respectively. OASCs were found to protect RPE cells from cell death and were demonstrated to increase early RPE precursor markers, while ABASCs showed a raise in retinal precursor marker expression. Subretinal transplantation of OASCs in a mouse model of retinal degeneration led to restoration of the RPE layer while transplantation of ABASCs resulted in a significant restoration of the photoreceptor layer. Taken together, we demonstrated a lineage-specific therapeutic effect for either OASCs or ABASCs in retinal regeneration.
UR - http://www.scopus.com/inward/record.url?scp=85118544190&partnerID=8YFLogxK
U2 - 10.1155/2021/7022247
DO - 10.1155/2021/7022247
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C2 - 34712333
AN - SCOPUS:85118544190
SN - 1687-966X
VL - 2021
JO - Stem Cells International
JF - Stem Cells International
M1 - 7022247
ER -