TY - GEN
T1 - Retinal ganglion cell apoptotic pathway in glaucoma
T2 - Initiating and downstream mechanisms
AU - Levkovitch-Verbin, Hani
PY - 2015
Y1 - 2015
N2 - Apoptosis of retinal ganglion cells (RGCs) in glaucoma causes progressive visual field loss, making it the primary cause of irreversible blindness worldwide. Elevated intraocular pressure and aging, the main risk factors for glaucoma, accelerate RGC apoptosis. Numerous pathways and mechanisms were found to be involved in RGC death in glaucoma. Neurotrophic factors deprivation is an early event. Oxidative stress, mitochondrial dysfunction, inflammation, glial cell dysfunction, and activation of apoptotic pathways and prosurvival pathways play a significant role in RGC death in glaucoma. The most important among the involved pathways are the MAP-kinase pathway, PI-3 kinase/Akt pathway, Bcl-2 family, caspase family, and IAP family.
AB - Apoptosis of retinal ganglion cells (RGCs) in glaucoma causes progressive visual field loss, making it the primary cause of irreversible blindness worldwide. Elevated intraocular pressure and aging, the main risk factors for glaucoma, accelerate RGC apoptosis. Numerous pathways and mechanisms were found to be involved in RGC death in glaucoma. Neurotrophic factors deprivation is an early event. Oxidative stress, mitochondrial dysfunction, inflammation, glial cell dysfunction, and activation of apoptotic pathways and prosurvival pathways play a significant role in RGC death in glaucoma. The most important among the involved pathways are the MAP-kinase pathway, PI-3 kinase/Akt pathway, Bcl-2 family, caspase family, and IAP family.
KW - Apoptosis
KW - Bcl-2
KW - Caspase
KW - Glaucoma
KW - MAP kinase
KW - Optic nerve
KW - Retinal ganglion cells
KW - Signal transduction
UR - http://www.scopus.com/inward/record.url?scp=84948800300&partnerID=8YFLogxK
U2 - 10.1016/bs.pbr.2015.05.005
DO - 10.1016/bs.pbr.2015.05.005
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C2 - 26497784
AN - SCOPUS:84948800300
SN - 9780444635662
T3 - Progress in Brain Research
SP - 37
EP - 57
BT - Progress in Brain Research
A2 - Nucci, Carlo
A2 - Bagetta, Giacinto
PB - Elsevier B.V.
ER -