Responses of human medial temporal lobe neurons are modulated by stimulus repetition

Carlos Pedreira, Florian Mormann, Alexander Kraskov, Moran Cerf, Itzhak Fried, Christof Koch, Rodrigo Quian Quiroga

Research output: Contribution to journalArticlepeer-review

37 Scopus citations


Recent studies have reported the presence of single neurons with strong responses to visual inputs in the human medial temporal lobe. Here we show how repeated stimulus presentation - photos of celebrities and familiar individuals, landmark buildings, animals, and objects - modulates the firing rate of these cells: a consistent decrease in the neural activity was registered as images were repeatedly shown during experimental sessions. The effect of repeated stimulus presentation was not the same for all medial temporal lobe areas. These findings are consistent with the view that medial temporal lobe neurons link visual percepts to declarative memory.

Original languageEnglish
Pages (from-to)97-107
Number of pages11
JournalJournal of Neurophysiology
Issue number1
StatePublished - Jan 2010


FundersFunder number
National Institute of Neurological Disorders and StrokeR01NS033221
Medical Research CouncilG0701038


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