Responses in rat core auditory cortex are preserved during sleep spindle oscillations

Yaniv Sela, Vladyslav V. Vyazovskiy, Chiara Cirelli, Giulio Tononi, Yuval Nir

Research output: Contribution to journalArticlepeer-review

Abstract

Study Objectives: Sleep is defined as a reversible state of reduction in sensory responsiveness and immobility. A long-standing hypothesis suggests that a high arousal threshold during non-rapid eye movement (NREM) sleep is mediated by sleep spindle oscillations, impairing thalamocortical transmission of incoming sensory stimuli. Here we set out to test this idea directly by examining sensory-evoked neuronal spiking activity during natural sleep. Methods: We compared neuronal (n = 269) and multiunit activity (MUA), as well as local field potentials (LFP) in rat core auditory cortex (A1) during NREM sleep, comparing responses to sounds depending on the presence or absence of sleep spindles. Results: We found that sleep spindles robustly modulated the timing of neuronal discharges in A1. However, responses to sounds were nearly identical for all measured signals including isolated neurons, MUA, and LFPs (all differences < 10%). Furthermore, in 10% of trials, auditory stimulation led to an early termination of the sleep spindle oscillation around 150 250 msec following stimulus onset. Finally, active ON states and inactive OFF periods during slow waves in NREM sleep affected the auditory response in opposite ways, depending on stimulus intensity. Conclusions: Responses in core auditory cortex are well preserved regardless of sleep spindles recorded in that area, suggesting that thalamocortical sensory relay remains functional during sleep spindles, and that sensory disconnection in sleep is mediated by other mechanisms.

Original languageEnglish
Pages (from-to)1069-1082
Number of pages14
JournalSleep
Volume39
Issue number5
DOIs
StatePublished - 1 May 2016

Keywords

  • Auditory cortex
  • LFP
  • NREM sleep
  • Rat
  • Single-unit
  • Sleep spindles

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