Response to open peer commentary on the reporting of spurious associations: A reply to "Relating hippocampal neurogenesis to behavior: The danger of ignoring confounding variables" by Dr. Stanley Lazic

Benjamin K. Yee, Joram Feldon, Irene Knuesel

Research output: Contribution to journalComment/debate

Abstract

Often factors related to hippocampal neurogenesis also result in a myriad of confounding changes that might explain or mediate the concomitant effects in memory and learning performance. Dr. Lazic's article (2010) reiterates such concerns in interpreting the biological links between neurogenesis and learning in the context of aging as articulated previously by Baxter and Gallagher (2006). The correlative analysis published by Nyffeler et al. (2008) illustrates the problematic inherent to such an interpretation. We offer here a complimentary approach that is both intuitive and practical in the re-examination of the previously reported data set, which further supports Nyffeler et al.'s (2008) key findings and conclusion.

Original languageEnglish
Pages (from-to)2172-2175
Number of pages4
JournalNeurobiology of Aging
Volume31
Issue number12
DOIs
StatePublished - Dec 2010
Externally publishedYes

Keywords

  • Aging
  • Correlation
  • Doublecortin
  • Nestin
  • Neurogenesis
  • Partial correlation statistics

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