Response to Combination Cholinergic/Noradrenergic Treatments in a Patient With Alzheimer's Disease

Paul S. Aisen, Linda M. Bierer, Michael Davidson, Theresa M. Ryan, Ranti Kaminsky, Kenneth L. Davis

Research output: Contribution to journalArticlepeer-review

Abstract

A patient with probable Alzheimer's disease participated in four studies involving cholinergic and combination cholinergic/noradrenergic treatment regimens. This patient demonstrated clinically significant improvement only with the combination of physostigmine and clonidine. The implications of these findings are discussed with regard to strategies for neurotransmitter augmentation therapy for Alzheimer's disease.

Original languageEnglish
Pages (from-to)244-248
Number of pages5
JournalAmerican Journal of Geriatric Psychiatry
Volume1
Issue number3
DOIs
StatePublished - 1993
Externally publishedYes

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