RESPeRATE: The role of paced breathing in hypertension treatment

Relu Cernes, Reuven Zimlichman*

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

25 Scopus citations


Despite a good adherence to lifestyle modifications and antihypertensive drugs, hypertension remains resistant in more than one-third of patients, thus creating the need for additional strategies, including non-pharmacologic approaches. Slow and deep breathing ("paced breathing") associated in the past with meditation has a direct antihypertensive effect by increasing baroreflex sensitivity. With the method of guiding the pace of breathing, a US Food and Drug Administration-certified device, RESPeRATE, may offer an easy, efficient, inexpensive, and noninvasive option for treating hypertension. Multiple studies showed a significant reduction of blood pressure when RESPeRATE was evaluated in a home and office setting. In conclusion, this review outlines the pathophysiologic background of paced respiration, describes RESPeRATE clinical trials, and presents briefly other guided breathing alternatives.

Original languageEnglish
Pages (from-to)38-47
Number of pages10
JournalJournal of the American Society of Hypertension
Issue number1
StatePublished - 1 Jan 2015
Externally publishedYes


  • Baroreflex sensitivity
  • blood pressure
  • hypertension treatment
  • paced breathing


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