Resolution considerations in imaging of the cortical layers

Shlomi Lifshits, Omri Tomer, Ittai Shamir, Daniel Barazany, Galia Tsarfaty, Saharon Rosset, Yaniv Assaf*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

19 Scopus citations


The cortical layers are a finger print of brain development, function, connectivity and pathology. Obviously, the formation of the layers and their composition is essential to cognition and behavior. The layers were traditionally measured by histological means but recent studies utilizing MRI suggested that T1 relaxation imaging consist of enough contrast to separate the layers. Indeed extreme resolution, post mortem, studies demonstrated this phenomenon. Yet, one of the limiting factors of using T1 MRI to visualize the layers in neuroimaging research is partial volume effect. This happen when the image resolution is not high enough and two or more layers resides within the same voxel. In this paper we demonstrate that due to the physical small thickness of the layers it is highly unlikely that high resolution imaging could resolve the layers. By contrast, we suggest that low resolution multi T1 mapping conjugate with composition analysis could provide practical means for measuring the T1 layers. We suggest an acquisition platform that is clinically feasible and could quantify measures of the layers. The key feature of the suggested platform is that separation of the layers is better achieved in the T1 relaxation domain rather than in the spatial image domain.

Original languageEnglish
Pages (from-to)112-120
Number of pages9
StatePublished - 1 Jan 2018


FundersFunder number
Israel Innovation Authority
Israeli Ministry of Economy and Industry50647


    • Brain parcellation
    • Cortical layers
    • MRI resolution
    • Partial volume effect
    • T1 relaxation


    Dive into the research topics of 'Resolution considerations in imaging of the cortical layers'. Together they form a unique fingerprint.

    Cite this