Resistance of the Eegyptian mongoose to sarafotoxins

Avner Bdolah*, Elazar Kochva, Michael Ovadia, Sara Kinamon, Zvi Wollberg

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

10 Scopus citations


The Egyptian mongoose (Herpestes ichneumon) is known for its resistance to viperid and elapid venoms. The current work demonstrates that it is also resistant to the venom of Atractaspis and its most toxic component, sarafotoxin-b. Intravenous administration of this toxin, at a dose of about 13 times LD100 for mice, resulted in disturbance in electrocardiograms in the mongoose, which returned to normal after several hours. Sarafotoxin-b failed to induce contraction of mongoose aortal preparations. Endothelin-1, which was demonstrated in tissue extracts of the mongoose by immunological methods, induced contraction of the isolated mongoose aorta. This contraction, however, was greatly reduced when endothelin-I was applied on top of sarafotoxin-b. Binding studies revealed endothelin/sarafotoxin-specific binding sites in brain and cardiovascular preparations of the mongoose. It is suggested that some structural features of endothelin/sarafotoxin receptors in the mongoose enable them to differentiate between the two peptides.

Original languageEnglish
Pages (from-to)1251-1261
Number of pages11
Issue number8
StatePublished - Aug 1997


FundersFunder number
Rose and Norman Lederer


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