The phenomenon of resistance of aged cells to virus replication was investigated in aged L929 cell monolayers infected with Semliki Forest virus. By inhibiting the production and action of interferon, we showed that only about one-third of the 4·5 log restriction in virus replication could be attributed to the antiviral activity of the endogenous interferon. However, two-thirds of this restriction was found to be associated with the slowed-down metabolism of the aged cells. This was demonstrated by using an enhancing factor that possesses the capacity to boost the cellular metabolism of aged cells while at the same time abolishing cellular resistance to virus replication.
|Number of pages||8|
|State||Published - 1979|