Abstract
Objectives/Hypothesis: To investigate the risk of residual tympanic membrane (TM) perforation after intratympanic (IT) steroidal treatment administered via transtympanic injection compared with trans-tympanostomy tube (TyT). Study Design: Case series, systematic review and meta analysis. Methods: Data were retrieved from the medical files of an original cohort of all consecutive patients with sudden sensorineural hearing loss necessitating IT steroidal treatment in a tertiary medical center between January 1, 2016 and November 20, 2020. A systematic literature search of “MEDLINE” via “PubMed,” “Embase,” and “Web of Science” on comparable published cases was performed and meta-analysis was established. Results: Eighteen studies describing 818 ears were included in the quantitative meta-analysis in addition to a local cohort of 140 ears. The proportion of residual TM perforation was 1.11% and 1.14% (95% confidence interval: 0.01%–3.27% and 0.028%–2.38%) in the TyT and trans-tympanic groups, respectively, suggesting no significant difference in residual TM perforation risk between these techniques. Conclusion: IT steroid therapy via trans-TyT is not associated with more residual perforations than IT steroid therapy via transtympanic injections. Level of Evidence: NA Laryngoscope, 131:E2583–E2591, 2021.
Original language | English |
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Pages (from-to) | E2583-E2591 |
Journal | Laryngoscope |
Volume | 131 |
Issue number | 9 |
DOIs | |
State | Published - Sep 2021 |
Keywords
- Tympanostomy tube
- intratympanic steroids
- residual perforation
- sudden sensorineural hearing loss
- tympanic membrane perforation