Resident cardiac progenitor cells

Ayelet Itzhaki-Alfia, Jonathan Leor

Research output: Chapter in Book/Report/Conference proceedingChapterpeer-review

Abstract

Resident cardiac stem/progenitor cells are implicated in cell replacement, repair and maintenance of the myocardium. These cells are already committed to a specific cardiomyogenic pathway. Stimulation of these cells in injured hearts can open new options in cardiovascular regenerative medicine, and advance our approach to patients with end-stage heart failure. This chapter reviews some of the recent discoveries in the field of resident cardiac stem/progenitor cells, focusing first on human cardiac stem cell characteristics and reparative potential, including the concept of myocardial regeneration. In addition, we will briefly review recent clinical trials, controversies and unresolved issues.

Original languageEnglish
Title of host publicationAdult and Pluripotent Stem Cells
Subtitle of host publicationPotential for Regenerative Medicine of the Cardiovascular System
PublisherSpringer Netherlands
Pages21-35
Number of pages15
ISBN (Electronic)9789401786577
ISBN (Print)9401786569, 9789401786560
DOIs
StatePublished - 1 Dec 2013

Keywords

  • Cardiac progenitor cells
  • Clinical stem cell trials
  • Intermyocardial injection
  • Repair of myocardium
  • Resident cardiac stem cells
  • Self-renewal of cardiomyocytes
  • Stem cell transplantation

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