Research trends analysis of chronic hepatitis C versus nonalcoholic fatty liver disease: A literature review text-mining analysis of publications

Eyal Klang, Shelly Soffer, Lee Alper*, Orit Shimon, Yiftach Barash, Yana Davidov, Mariya Likhter, Oranit Cohen-Ezra, Gil Ben Yakov, Ziv Ben-Ari

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Hepatits C virus (HCV) rates have lowered due to direct-acting antiviral treatment. Nonalcoholic steatohepatitis (NASH)/nonalcoholic fatty liver disease (NAFLD) is rising with no available therapy. We employed text-mining to analyze trends in HCV and NAFLD research from the past two decades. Materials and Methods: We queried PubMed for all HCV and NASH/NAFLD entries published between 2000 and 2020. We compared the total number of publications on both etiologies. We performed subanalyses for different terms of interest and for geographic origin. Results: Overall, 75,934 HCV-related entries and 24,987 NASH/NAFLD-related entries were published during the study period. Up to 2015, there was a linear upward slope in the number of annual HCV publications (154.9 publications/year, p < 0.001). In 2015, the yearly number of HCV publications started showing a downward slope (−242.2 publications/year, p < 0.001). The number of NASH/NAFLD publications showed a continuous upward slope during the study period. The NASH/NAFLD field lacks publications on screening and treatment methods. Conclusion: Trends in publications varied between both etiologies. They reflect the success of antiviral treatment for HCV. The growing rates of NAFLD/NASH and the lack of a targeted cure explain the rise in related publications.

Original languageEnglish
Article numbere805
JournalHealth Science Reports
Volume5
Issue number6
DOIs
StatePublished - Nov 2022

Keywords

  • PubMed
  • chronic hepatitis C
  • nonalcoholic fatty liver disease
  • text mining

Fingerprint

Dive into the research topics of 'Research trends analysis of chronic hepatitis C versus nonalcoholic fatty liver disease: A literature review text-mining analysis of publications'. Together they form a unique fingerprint.

Cite this