Research domain criteria (Rdoc): A perspective to probe the biological background behind treatment efficacy in depression

Marco Calabrò, Chiara Fabbri, Siegfried Kasper, Joseph Zohar, Daniel Souery, Stuart Montgomery, Diego Albani, Gianluigi Forloni, Panagiotis Ferentinos, Dan Rujescu, Julien Mendlewicz, Roberto Colombo, Diana De Ronchi, Alessandro Serretti, Concetta Crisafulli

Research output: Contribution to journalArticlepeer-review


Background: Major Depressive Disorder(MDD) and its frequent partial response to antidepressants are a major health concern and therefore an important focus of research. Despite the efforts, MDD pathogenesis and the mechanisms of antidepressant action are only partially understood. In the last few years, the need of rethinking the classification of depressive disorders and psychiatric disorders, in general, has been suggested, in order to provide a nosology that reflects more closely the biological background associated with disease pathogenesis and its role/significance in treatment. The classification proposed by the National Institute of Mental Health (NIMH), namely the research domain criteria (RDoC), may represent a key framework to guide research in this direction. Methods: A literature search was performed on PubMed and Google Scholar databases in order to retrieve data regarding Antidepressants effects on specific RDoC constructs. Further, the targets of drugs of interest were identified through the Drug bank database, and their possible function within RDoC constructs was discussed. Discussion: In this review, we summarize and discuss the significance of the results of pre-clinical and clinical studies investigating specific RDoC paradigms relevant to depressive phenotypes and antidepressant effects. Conclusion: The RDoC framework may facilitate a more specific use of antidepressants based on the individual’s spectrum of symptoms and the development of new compounds that target specific depressive symptoms.

Original languageEnglish
Pages (from-to)4296-4320
Number of pages25
JournalCurrent Medicinal Chemistry
Issue number22
StatePublished - 2021


  • Antidepressant
  • Behavioral paradigm
  • Drug targets
  • Major depressive disorder
  • RDoC Constructs
  • Research domain criteria


Dive into the research topics of 'Research domain criteria (Rdoc): A perspective to probe the biological background behind treatment efficacy in depression'. Together they form a unique fingerprint.

Cite this