Reprogramming cells for transplantation

Jonathan Leor, Alexander Battler, Robert A. Kloner, Sharon Etzion

Research output: Contribution to journalReview articlepeer-review

Abstract

The field of tissue engineering, involving the reprogramming of stem cells or rejuvenation of specific differentiated cells, is emerging as a promising strategy to repair the damaged myocardium. The eventual goal is to be able to take a patient's own cells, expand them ex vivo, genetically engineer them to enhance specific properties, and then reintroduce them into the patient's heart to create a replacement tissue. Our review paper describes data that supports the potential of this strategy. This clinically relevant, combined strategy of genetic and tissue engineering could be of importance in treating elderly patients with massive myocardial damage, patients whose normal myogenic or angiogenic cells have been depleted or are inadequate in their growth potential, to prevent LV deterioration and heart failure.

Original languageEnglish
Pages (from-to)285-292
Number of pages8
JournalHeart Failure Reviews
Volume8
Issue number3
DOIs
StatePublished - Jul 2003
Externally publishedYes

Keywords

  • Cell transplantation
  • Cloning
  • Gene
  • Gene therapy,
  • MyoD
  • Telomerase
  • Tissue engineering

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