TY - JOUR
T1 - Reprogramming cells for transplantation
AU - Leor, Jonathan
AU - Battler, Alexander
AU - Kloner, Robert A.
AU - Etzion, Sharon
N1 - Funding Information:
This work was supported by grant No. 98-414 from the United States-Israel Binational Science Foundation. Dr Kloner is supported by a grant from the National Heart, Lung and Blood Institute HL 61488.
PY - 2003/7
Y1 - 2003/7
N2 - The field of tissue engineering, involving the reprogramming of stem cells or rejuvenation of specific differentiated cells, is emerging as a promising strategy to repair the damaged myocardium. The eventual goal is to be able to take a patient's own cells, expand them ex vivo, genetically engineer them to enhance specific properties, and then reintroduce them into the patient's heart to create a replacement tissue. Our review paper describes data that supports the potential of this strategy. This clinically relevant, combined strategy of genetic and tissue engineering could be of importance in treating elderly patients with massive myocardial damage, patients whose normal myogenic or angiogenic cells have been depleted or are inadequate in their growth potential, to prevent LV deterioration and heart failure.
AB - The field of tissue engineering, involving the reprogramming of stem cells or rejuvenation of specific differentiated cells, is emerging as a promising strategy to repair the damaged myocardium. The eventual goal is to be able to take a patient's own cells, expand them ex vivo, genetically engineer them to enhance specific properties, and then reintroduce them into the patient's heart to create a replacement tissue. Our review paper describes data that supports the potential of this strategy. This clinically relevant, combined strategy of genetic and tissue engineering could be of importance in treating elderly patients with massive myocardial damage, patients whose normal myogenic or angiogenic cells have been depleted or are inadequate in their growth potential, to prevent LV deterioration and heart failure.
KW - Cell transplantation
KW - Cloning
KW - Gene
KW - Gene therapy,
KW - MyoD
KW - Telomerase
KW - Tissue engineering
UR - http://www.scopus.com/inward/record.url?scp=0042564566&partnerID=8YFLogxK
U2 - 10.1023/A:1024786020652
DO - 10.1023/A:1024786020652
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AN - SCOPUS:0042564566
SN - 1382-4147
VL - 8
SP - 285
EP - 292
JO - Heart Failure Reviews
JF - Heart Failure Reviews
IS - 3
ER -
