Reproducibility of microvolt T-wave alternans in patients with coronary artery disease

Therese Fuchs, Marina Leitman, Itzhak Zysman, Tal Amini, Amram Torjman

Research output: Contribution to journalArticlepeer-review

Abstract

Background: Microvolt T-wave alternans (MTWA) measures subtle beat-to-beat fluctuations in the T-wave amplitude. It was found to be associated with cardiac electrical instability in patients with ischemic and dilated cardiomyopathy. Objectives: To investigate the reproducibility of the MTWA test results in patients with ischemic heart disease. Methods: The study group comprised patients with ischemic heart disease who participated in a rehabilitation program at the Assaf Harofeh Medical Center. MTWA was measured during a bicycle exercise test at the first encounter and repeated after one week. Results: Of the 40 study patients with coronary artery disease, 4 had an indeterminate result and were excluded from the data analysis; 5 had a positive MTWA in the first and second study (14%), 27 had a negative MTWA in the first and second study (75%), and 4 had a negative MTWA in the first study and a positive MTWA in the second study (11%). Overall, there was a correlation between the results of the first and the second study in 89% of the patients (kappa = 0.652, P = 0.0001). Conclusions: MTWA measurements are reproducible in the short term in patients with coronary artery disease.

Original languageEnglish
Pages (from-to)359-362
Number of pages4
JournalIsrael Medical Association Journal
Volume14
Issue number6
StatePublished - Jun 2012

Keywords

  • Ischemic heart disease
  • Reproducibility
  • T-wave alternans (TWA)

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