TY - JOUR
T1 - Reproducibility of microvolt T-wave alternans in patients with coronary artery disease
AU - Fuchs, Therese
AU - Leitman, Marina
AU - Zysman, Itzhak
AU - Amini, Tal
AU - Torjman, Amram
PY - 2012/6
Y1 - 2012/6
N2 - Background: Microvolt T-wave alternans (MTWA) measures subtle beat-to-beat fluctuations in the T-wave amplitude. It was found to be associated with cardiac electrical instability in patients with ischemic and dilated cardiomyopathy. Objectives: To investigate the reproducibility of the MTWA test results in patients with ischemic heart disease. Methods: The study group comprised patients with ischemic heart disease who participated in a rehabilitation program at the Assaf Harofeh Medical Center. MTWA was measured during a bicycle exercise test at the first encounter and repeated after one week. Results: Of the 40 study patients with coronary artery disease, 4 had an indeterminate result and were excluded from the data analysis; 5 had a positive MTWA in the first and second study (14%), 27 had a negative MTWA in the first and second study (75%), and 4 had a negative MTWA in the first study and a positive MTWA in the second study (11%). Overall, there was a correlation between the results of the first and the second study in 89% of the patients (kappa = 0.652, P = 0.0001). Conclusions: MTWA measurements are reproducible in the short term in patients with coronary artery disease.
AB - Background: Microvolt T-wave alternans (MTWA) measures subtle beat-to-beat fluctuations in the T-wave amplitude. It was found to be associated with cardiac electrical instability in patients with ischemic and dilated cardiomyopathy. Objectives: To investigate the reproducibility of the MTWA test results in patients with ischemic heart disease. Methods: The study group comprised patients with ischemic heart disease who participated in a rehabilitation program at the Assaf Harofeh Medical Center. MTWA was measured during a bicycle exercise test at the first encounter and repeated after one week. Results: Of the 40 study patients with coronary artery disease, 4 had an indeterminate result and were excluded from the data analysis; 5 had a positive MTWA in the first and second study (14%), 27 had a negative MTWA in the first and second study (75%), and 4 had a negative MTWA in the first study and a positive MTWA in the second study (11%). Overall, there was a correlation between the results of the first and the second study in 89% of the patients (kappa = 0.652, P = 0.0001). Conclusions: MTWA measurements are reproducible in the short term in patients with coronary artery disease.
KW - Ischemic heart disease
KW - Reproducibility
KW - T-wave alternans (TWA)
UR - http://www.scopus.com/inward/record.url?scp=84863320539&partnerID=8YFLogxK
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C2 - 22891396
AN - SCOPUS:84863320539
SN - 1565-1088
VL - 14
SP - 359
EP - 362
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 6
ER -
