Report of the ECCO pathogenesis workshop on anti-TNF therapy failures in inflammatory bowel diseases: Definitions, frequency and pharmacological aspects

Matthieu Allez*, Konstantinos Karmiris, Edouard Louis, Gert Van Assche, Shomron Ben-Horin, Amir Klein, Janneke Van der Woude, Filip Baert, Rami Eliakim, Konstantinos Katsanos, Jørn Brynskov, Flavio Steinwurz, Silvio Danese, Severine Vermeire, Jean Luc Teillaud, Marc Lémann, Yehuda Chowers

*Corresponding author for this work

Research output: Contribution to journalReview articlepeer-review

288 Scopus citations

Abstract

The first ECCO pathogenesis workshop focused on anti-TNF therapy failures in inflammatory bowel diseases (IBDs). The overall objective was to better understand and explore primary non response and loss of response to anti-TNF agents in IBD. The outcome of this workshop is presented into two parts. This first section addresses definitions, frequency and pharmacological aspects of anti-TNF therapy failure, including pharmacokinetics of anti-TNF monoclonal antibodies and immune and non-immune mediated clearance of anti-TNF mAbs. The second section concerns the biological roles of TNF and TNF antagonists, including mechanisms of action of anti-TNF agents, and discuss hypothesis regarding their failures and phenomenon of paradoxical inflammation, including the potential role of TNF independent inflammatory pathways.

Original languageEnglish
Pages (from-to)355-366
Number of pages12
JournalJournal of Crohn's and Colitis
Volume4
Issue number4
DOIs
StatePublished - Oct 2010
Externally publishedYes

Funding

FundersFunder number
Abbott Laboratories

    Keywords

    • Anti-TNF therapy
    • Crohn's disease
    • Immunogenicity
    • Inflammatory bowel diseases
    • Pharmacology
    • Ulcerative colitis

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