Replacing the carbonyl's oxygen with the difluoromethyl group

Or Cohen, Youlia Hagooly, Shlomo Rozen

Research output: Contribution to journalArticlepeer-review


Aldehydes or ketones were reacted with 2-(trimethylsilyl)-1,3-dithiane (1) and the products reduced to the corresponding dithianes using tetrafluoroboric acid and sodium borohydride. These sulfur containing compounds were reacted with bromine trifluoride under mild conditions (1-2 min, 0 °C) with a net result of replacing the carbonyls' oxygen with the desired difluoromethyl moiety.

Original languageEnglish
Pages (from-to)1361-1365
Number of pages5
Issue number7
StatePublished - 14 Feb 2009


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