repfdr: a tool for replicability analysis for genome-wide association studies

Research output: Contribution to journalArticlepeer-review


MOTIVATION: Identification of single nucleotide polymorphisms that are associated with a phenotype in more than one study is of great scientific interest in the genome-wide association studies (GWAS) research. The empirical Bayes approach for discovering whether results have been replicated across studies was shown to be a reliable method, and close to optimal in terms of power.

RESULTS: The R package repfdr provides a flexible implementation of the empirical Bayes approach for replicability analysis and meta-analysis, to be used when several studies examine the same set of null hypotheses. The usefulness of the package for the GWAS community is discussed.

AVAILABILITY AND IMPLEMENTATION: The R package repfdr can be downloaded from CRAN.


SUPPLEMENTARY INFORMATION: Supplementary data are available at Bioinformatics online.

Original languageEnglish
Pages (from-to)2971-2972
Number of pages2
Issue number20
StatePublished - 15 Oct 2014


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