TY - JOUR
T1 - Repeated swim stress leads to down-regulation of vesicular monoamine transporter 2 in rat brain nucleus accumbens and striatum
AU - Zucker, Michal
AU - Weizman, Abraham
AU - Rehavi, Moshe
PY - 2005/3
Y1 - 2005/3
N2 - We assessed the impact of chronic swim stress in rats (daily for 3 weeks) on vesicular monoamine transporter 2 (VMAT2) in the nucleus accumbens and striatum. Exposure to repeated swim stress resulted in significant reduction in VMAT2 density in nucleus accumbens (20%, p<0.01) and striatum subregions (21-38%, p<0.001). The down-regulation of VMAT2 in this dopaminergic regions may serve as an adaptatory mechanism in the response to prolonged stress, and may be relevant to chronic stress-induced depression.
AB - We assessed the impact of chronic swim stress in rats (daily for 3 weeks) on vesicular monoamine transporter 2 (VMAT2) in the nucleus accumbens and striatum. Exposure to repeated swim stress resulted in significant reduction in VMAT2 density in nucleus accumbens (20%, p<0.01) and striatum subregions (21-38%, p<0.001). The down-regulation of VMAT2 in this dopaminergic regions may serve as an adaptatory mechanism in the response to prolonged stress, and may be relevant to chronic stress-induced depression.
KW - Depression
KW - Dopamine
KW - Nucleus accumbens
KW - Stress
KW - Striatum
KW - Vesicular monoamine transporter
UR - http://www.scopus.com/inward/record.url?scp=13244266994&partnerID=8YFLogxK
U2 - 10.1016/j.euroneuro.2004.08.009
DO - 10.1016/j.euroneuro.2004.08.009
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AN - SCOPUS:13244266994
SN - 0924-977X
VL - 15
SP - 199
EP - 201
JO - European Neuropsychopharmacology
JF - European Neuropsychopharmacology
IS - 2
ER -