Repeated swim stress leads to down-regulation of vesicular monoamine transporter 2 in rat brain nucleus accumbens and striatum

Michal Zucker, Abraham Weizman, Moshe Rehavi*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

We assessed the impact of chronic swim stress in rats (daily for 3 weeks) on vesicular monoamine transporter 2 (VMAT2) in the nucleus accumbens and striatum. Exposure to repeated swim stress resulted in significant reduction in VMAT2 density in nucleus accumbens (20%, p<0.01) and striatum subregions (21-38%, p<0.001). The down-regulation of VMAT2 in this dopaminergic regions may serve as an adaptatory mechanism in the response to prolonged stress, and may be relevant to chronic stress-induced depression.

Original languageEnglish
Pages (from-to)199-201
Number of pages3
JournalEuropean Neuropsychopharmacology
Volume15
Issue number2
DOIs
StatePublished - Mar 2005

Keywords

  • Depression
  • Dopamine
  • Nucleus accumbens
  • Stress
  • Striatum
  • Vesicular monoamine transporter

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