Repeated swim stress and peripheral-type benzodiazepine receptors

Ruth Burgin; Ronit Weizman; Moshe Gavish

doi:10.1159/000119245

Repeated swim stress and peripheral-type benzodiazepine receptors

Ruth Burgin, Ronit Weizman, Moshe Gavish^*

^*Corresponding author for this work

Clinical Departments

Technion-Israel Institute of Technology

Research output: Contribution to journal › Article › peer-review

22 Scopus citations

Abstract

The effect of daily forced swimming (15 min) of rats for 21 consecutive days on peripheral-type bentodiazepine receptors (PBR) was investigated. A significant reduction (−17%; p < 0.05) was observed in renal PBR in the stressed animals. A nonsignificant reduction of −18% was detected in adrenal PBR. The maximal binding capacity of [³H]PK 11195 was unaltered in the liver, heart, testis and thymus. It seems that the kidney is especially sensitive to repeated stress. The renal PBR reduction may be related to habituation to stress, and may reflect an adaptatory mechanism aimed at preventing long-term stress-induced overactivity of the reninangiotensin system.

Original language	English
Pages (from-to)	28-31
Number of pages	4
Journal	Neuropsychobiology
Volume	33
Issue number	1
DOIs	https://doi.org/10.1159/000119245
State	Published - 1996

Keywords

Peripheral-type benzodiazepine receptor
Swim stress
[H]PK 11195

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Repeated swim stress and peripheral-type benzodiazepine receptors

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