Repeated swim stress and peripheral-type benzodiazepine receptors

Ruth Burgin, Ronit Weizman, Moshe Gavish*

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review


The effect of daily forced swimming (15 min) of rats for 21 consecutive days on peripheral-type bentodiazepine receptors (PBR) was investigated. A significant reduction (−17%; p < 0.05) was observed in renal PBR in the stressed animals. A nonsignificant reduction of −18% was detected in adrenal PBR. The maximal binding capacity of [3H]PK 11195 was unaltered in the liver, heart, testis and thymus. It seems that the kidney is especially sensitive to repeated stress. The renal PBR reduction may be related to habituation to stress, and may reflect an adaptatory mechanism aimed at preventing long-term stress-induced overactivity of the reninangiotensin system.

Original languageEnglish
Pages (from-to)28-31
Number of pages4
Issue number1
StatePublished - 1996


  • Peripheral-type benzodiazepine receptor
  • Swim stress
  • [H]PK 11195


Dive into the research topics of 'Repeated swim stress and peripheral-type benzodiazepine receptors'. Together they form a unique fingerprint.

Cite this