TY - JOUR
T1 - Repeated intravenous amantadine infusions in advanced parkinsonism
T2 - Experience of a large movement disorder center
AU - Kestenbaum, Meir
AU - Snineh, Muneer Abu
AU - Nussbaum, Tamar
AU - Gadoth, Avi
AU - Rosenberg, Alina
AU - Hindi, Avigail
AU - Zitser, Jennifer
AU - Thaler, Avner
AU - Giladi, Nir
AU - Gurevich, Tanya
N1 - Publisher Copyright:
© 2019 Israel Medical Association. All rights reserved.
PY - 2019
Y1 - 2019
N2 - Background: The effect of repeated intravenous amantadine (IVAM) in advanced Parkinsonism has not been studied in depth. Objectives: To report the experience of our medical center with repeated IVAM infusions in patients with advanced Parkinsonism. Methods: Thirty patients with advanced Parkinsonism of various etiologies were enrolled in an open-label retrospective study. All patients were treated with IVAM infusions in a neurological daycare center. Treatment was initiated with a loading dose of 200/400 mg per day for 5 days followed by a once-daily maintenance dose of 200/400 mg every 1 to 3 weeks. Patients and their caregivers participated in a structured interview and independently completed a clinical global impression of changes scale questionnaire on various motor and non-motor symptoms. Results: Patient mean age was 73.3 ± 9.7 years, average disease duration was 6.2 ± 5.7 years, and mean Hoehn and Yahr score was 3.2 ± 0.84. Mean duration of the IVAM treatment was 15.1 ± 11.6 months. An improvement in general function was reported by 91% of the patients and 89% of the caregivers. Most of the patients reported improvement in tremor and rigidity, as well as in gait stability, freezing of gait, and reduced falls. The treatment was safe with few side effects. Conclusions: Our data suggest that repeated IVAM infusions could be an effective treatment against various motor symptoms and for improvement of mobility in patients with advanced Parkinsonism. Further randomized clinical trials with a larger sample size using objective measures are warranted to validate our results.
AB - Background: The effect of repeated intravenous amantadine (IVAM) in advanced Parkinsonism has not been studied in depth. Objectives: To report the experience of our medical center with repeated IVAM infusions in patients with advanced Parkinsonism. Methods: Thirty patients with advanced Parkinsonism of various etiologies were enrolled in an open-label retrospective study. All patients were treated with IVAM infusions in a neurological daycare center. Treatment was initiated with a loading dose of 200/400 mg per day for 5 days followed by a once-daily maintenance dose of 200/400 mg every 1 to 3 weeks. Patients and their caregivers participated in a structured interview and independently completed a clinical global impression of changes scale questionnaire on various motor and non-motor symptoms. Results: Patient mean age was 73.3 ± 9.7 years, average disease duration was 6.2 ± 5.7 years, and mean Hoehn and Yahr score was 3.2 ± 0.84. Mean duration of the IVAM treatment was 15.1 ± 11.6 months. An improvement in general function was reported by 91% of the patients and 89% of the caregivers. Most of the patients reported improvement in tremor and rigidity, as well as in gait stability, freezing of gait, and reduced falls. The treatment was safe with few side effects. Conclusions: Our data suggest that repeated IVAM infusions could be an effective treatment against various motor symptoms and for improvement of mobility in patients with advanced Parkinsonism. Further randomized clinical trials with a larger sample size using objective measures are warranted to validate our results.
KW - Intravenous amantadine (IVAM)
KW - Parkinson's disease (PD)
KW - Parkinsonism
UR - http://www.scopus.com/inward/record.url?scp=85076311603&partnerID=8YFLogxK
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C2 - 31814345
AN - SCOPUS:85076311603
SN - 1565-1088
VL - 21
SP - 812
EP - 816
JO - Israel Medical Association Journal
JF - Israel Medical Association Journal
IS - 12
ER -