TY - JOUR
T1 - Renal Transplantation in the Amyloidosis of Familial Mediterranean Fever
T2 - Experience in Ten Cases
AU - Jacob, Erwin T.
AU - Bar Nathan, Nathan
AU - Shapira, Zaki
AU - Gafni, Joseph
PY - 1979/10
Y1 - 1979/10
N2 - Ten patients with familial Mediterranean fever (FMF) and histologically confirmed amyloidosis received cadaver kidney transplants for treatment of terminal renal disease. Colchicine, 1 mg daily, was included in the routine postoperative regimen from 1974 for amyloidotic patients. Graft and patient survival were compared with ten nonamyloidotic recipients of renal grafts matched for age, sex, type of allograft, and HLA compatibility. In the FMF group, five of ten grafts have survived from 20 to 64 months; in the control group, six of ten. While only recipients with functioning grafts survived in the FMF group, patient survival in the control group is eight of ten after one year. In all five FMF survivors, graft function is satisfactory, proteinuria is absent, and blood creatinine levels are normal. Amyloid involvement of an allograft was documented 16 months after transplantation in the only patient whose maintenance colchicine dosage had been reduced to 0.5 mg daily.
AB - Ten patients with familial Mediterranean fever (FMF) and histologically confirmed amyloidosis received cadaver kidney transplants for treatment of terminal renal disease. Colchicine, 1 mg daily, was included in the routine postoperative regimen from 1974 for amyloidotic patients. Graft and patient survival were compared with ten nonamyloidotic recipients of renal grafts matched for age, sex, type of allograft, and HLA compatibility. In the FMF group, five of ten grafts have survived from 20 to 64 months; in the control group, six of ten. While only recipients with functioning grafts survived in the FMF group, patient survival in the control group is eight of ten after one year. In all five FMF survivors, graft function is satisfactory, proteinuria is absent, and blood creatinine levels are normal. Amyloid involvement of an allograft was documented 16 months after transplantation in the only patient whose maintenance colchicine dosage had been reduced to 0.5 mg daily.
UR - http://www.scopus.com/inward/record.url?scp=0018580930&partnerID=8YFLogxK
U2 - 10.1001/archinte.1979.03630470047016
DO - 10.1001/archinte.1979.03630470047016
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AN - SCOPUS:0018580930
SN - 0003-9926
VL - 139
SP - 1135
EP - 1138
JO - Archives of Internal Medicine
JF - Archives of Internal Medicine
IS - 10
ER -