Renal prostaglandin production is increased during abdominal sepsis in the rat and unaffected by the infusion of different amino acid formulations

Herbert R. Freund*, Uno O. Barcelli, Michael Muggia-Sullam, Richard LaFrance, Lois S. Gallon, Josef E. Fischer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

3 Scopus citations

Abstract

Renal prostaglandin (PG) production was studied in 32 laparotomized (control) and 33 septic rats (cecal ligation and puncture). Control and septic rats were infused for 18 hr with 5% glucose or 5% glucose and one of three amino acid formulations containing 22, 35, or 45% branched chain amino acids. When comparing renal PG production from endogenous precursors in septic versus control rats, significant increases (P < 0.01) could be detected for PGE2, 6-keto-PGF, and TxB2. The infusion of either 5% glucose alone or 5% glucose with 4.25% of any of the three amino acid formulations tested did not change renal PG production in either control or septic rats.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalJournal of Surgical Research
Volume44
Issue number2
DOIs
StatePublished - Feb 1988
Externally publishedYes

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