Renal prostaglandin production is increased during abdominal sepsis in the rat and unaffected by the infusion of different amino acid formulations

Herbert R. Freund*, Uno O. Barcelli, Michael Muggia-Sullam, Richard LaFrance, Lois S. Gallon, Josef E. Fischer

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Renal prostaglandin (PG) production was studied in 32 laparotomized (control) and 33 septic rats (cecal ligation and puncture). Control and septic rats were infused for 18 hr with 5% glucose or 5% glucose and one of three amino acid formulations containing 22, 35, or 45% branched chain amino acids. When comparing renal PG production from endogenous precursors in septic versus control rats, significant increases (P < 0.01) could be detected for PGE2, 6-keto-PGF, and TxB2. The infusion of either 5% glucose alone or 5% glucose with 4.25% of any of the three amino acid formulations tested did not change renal PG production in either control or septic rats.

Original languageEnglish
Pages (from-to)99-103
Number of pages5
JournalJournal of Surgical Research
Volume44
Issue number2
DOIs
StatePublished - Feb 1988
Externally publishedYes

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