TY - JOUR
T1 - Renal prostaglandin production is increased during abdominal sepsis in the rat and unaffected by the infusion of different amino acid formulations
AU - Freund, Herbert R.
AU - Barcelli, Uno O.
AU - Muggia-Sullam, Michael
AU - LaFrance, Richard
AU - Gallon, Lois S.
AU - Fischer, Josef E.
PY - 1988/2
Y1 - 1988/2
N2 - Renal prostaglandin (PG) production was studied in 32 laparotomized (control) and 33 septic rats (cecal ligation and puncture). Control and septic rats were infused for 18 hr with 5% glucose or 5% glucose and one of three amino acid formulations containing 22, 35, or 45% branched chain amino acids. When comparing renal PG production from endogenous precursors in septic versus control rats, significant increases (P < 0.01) could be detected for PGE2, 6-keto-PGF1α, and TxB2. The infusion of either 5% glucose alone or 5% glucose with 4.25% of any of the three amino acid formulations tested did not change renal PG production in either control or septic rats.
AB - Renal prostaglandin (PG) production was studied in 32 laparotomized (control) and 33 septic rats (cecal ligation and puncture). Control and septic rats were infused for 18 hr with 5% glucose or 5% glucose and one of three amino acid formulations containing 22, 35, or 45% branched chain amino acids. When comparing renal PG production from endogenous precursors in septic versus control rats, significant increases (P < 0.01) could be detected for PGE2, 6-keto-PGF1α, and TxB2. The infusion of either 5% glucose alone or 5% glucose with 4.25% of any of the three amino acid formulations tested did not change renal PG production in either control or septic rats.
UR - http://www.scopus.com/inward/record.url?scp=0023832075&partnerID=8YFLogxK
U2 - 10.1016/0022-4804(88)90036-4
DO - 10.1016/0022-4804(88)90036-4
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AN - SCOPUS:0023832075
SN - 0022-4804
VL - 44
SP - 99
EP - 103
JO - Journal of Surgical Research
JF - Journal of Surgical Research
IS - 2
ER -