Renal outcome and vascular morbidity in Systemic Lupus Erythematosus (SLE): Lack of association with the angiotensin-converting enzyme gene polymorphism

Yair Molad, Eyal Gal, Nurit Magal, Jaqueline Sulkes, Masha Mukamel, Abraham Weinberger, Shadan Lalazari, Mordechai Shohat

Research output: Contribution to journalArticlepeer-review

Abstract

Objectives: The angiotensin-converting enzyme (ACE) gene polymorphism has been associated with worse outcome in various chronic glomerular disorders and in hypertension. Because nephritis and vascular morbidity are prominent determinants of outcome in systemic lupus erythematosus (SLE), we studied the distribution and prognostic effect the ACE genotype might have on the outcome of SLE. Methods: Fifty-six consecutive Israeli SLE patients and 48 (sex and ethnic origin matched) healthy individuals were evaluated for the ACE genotype by a polymerase chain reaction-based assay. The clinical and laboratory parameters of the patients as well as the SLE disease activity index (SLEDAI) and the presence of hypertension, diabetes mellitus, ischemic heart disease, congestive heart failure, and stroke were correlated with the ACE genotype. Results: The distribution of the ACE genotype D/D, D/I, and I/I in the lupus group was 59%, 36%, and 5%, respectively, similar to the distribution in the control group (54%, 31%, and 15%, respectively). We failed to find any significant association between the ACE genotype and disease manifestations, SLEDAI, renal function, or cardiovascular and cerebrovascular morbidity. The clinical and laboratory parameters associated with renal outcome and vascular morbidity in our cohort are described. Conclusions: No difference was found between the distribution of the ACE genotype in lupus patients and the general population in Israel. Renal function as well as cardiovascular and cerebrovascular morbidity among Israeli patients with SLE are disease-related and independent of the ACE gene polymorphism. Copyright (C) 2000 by W.B. Saunders Company.

Original languageEnglish
Pages (from-to)132-137
Number of pages6
JournalSeminars in Arthritis and Rheumatism
Volume30
Issue number2
DOIs
StatePublished - 2000

Keywords

  • Angiotensin-converting enzyme gene
  • Cardiovascular
  • Outcome
  • Polymorphism
  • Renal
  • SLE disease activity index
  • Stroke
  • Systemic lupus erythematosus

Fingerprint

Dive into the research topics of 'Renal outcome and vascular morbidity in Systemic Lupus Erythematosus (SLE): Lack of association with the angiotensin-converting enzyme gene polymorphism'. Together they form a unique fingerprint.

Cite this