Renal function in patients with cystic fibrosis

M. Aladjem, D. Lotan, H. Boichis, S. Orda, D. Katznelson

Research output: Contribution to journalArticlepeer-review

19 Scopus citations

Abstract

Renal handling of sodium, potassium, calcium and phosphorus was investigated in 9 patients with cystic fibrosis (CF). Both under baseline and during saline-induced diuresis, urinary excretion rate of sodium (UNaV), potassium, phosphorus and calcium did not differ significantly from control values although the fractional excretion of sodium was significantly higher in patients with CF during saline diuresis. When distally acting diuretics were administered, this difference between CF patients and controls was magnified and in addition, UNaV in CF patients was also significantly higher than in controls. Following saline loading the increment in glomerular filtration rate (GFR) in patients with CF was significantly lower than of controls. We conclude that patients with CF when subjected to volume expansion demonstrate a lower tubular reabsorptive capacity of sodium as well as a reduced ability to increase their GFR. The defect in sodium reabsorption is probably located in the proximal tubule.

Original languageEnglish
Pages (from-to)84-86
Number of pages3
JournalUnknown Journal
Volume34
Issue number2
DOIs
StatePublished - 1983
Externally publishedYes

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