Renal function after tumor enucleation: Assessment by quantitative SPECT of 99mTc-dimercaptosuccinic acid uptake by the kidneys

David Groshar*, Boaz Moskovitz, Alexander Kastin, Elias Issaq, Ofer Nativ

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

The purpose of this study was to evaluate the amount of functioning renal mass removed and the amount of remaining individual renal function after tumor enucleation. Methods: Renal functional volume, percentage injected dose (%ID) per cubic centimeter of renal tissue and individual renal uptake of 24 operated and 24 contralateral kidneys were studied by two sequential SPECT quantitations of 99mTc-dimercaptosuccinic acid (DMSA) uptake by the kidneys (QDMSA). The first study was before surgery and the second study was 1 to 6 mo (mean 3.5 mo) after surgery. Mean tumor size was 3.4 ± 0.99 cm and all tumors were confined to the renal parenchyma (stages pT1 and pT2). Results: In the operated kidneys, there was a statistically significant decrease in renal cortical volume (170 ± 46 mL after surgery versus 207 ± 45 mL before surgery, t = 6.2, P < 0.001) and individual renal uptake (10.3% ± 3.0% after surgery versus 13.0% ± 2.9% before surgery, t = 5.4, P< 0.001). There was no statistically significant change after surgery compared with before surgery in the %ID per cubic centimeter of renal tissue of the operated kidneys, and in the volume, %ID per cubic centimeter and uptake of the contralateral normal kidneys. Conclusion: The results suggest that QDMSA is a noninvasive method able to assess changes in separate renal function. The limited functioning parenchymal loss after tumor enucleation had no effect on the opposite kidneys.

Original languageEnglish
Pages (from-to)968-971
Number of pages4
JournalJournal of Nuclear Medicine
Volume40
Issue number6
StatePublished - Jun 1999
Externally publishedYes

Keywords

  • Renal function
  • Renal tumors
  • SPECT
  • Tc-dimercaptosuccinic acid

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