TY - JOUR
T1 - Renal effects of parenteral fish oil administered to heart-beating organ donors and renal-transplant recipients
T2 - A tolerance study
AU - Singer, Pierre
AU - Zolotarski, Victor
AU - Yussim, Alex
AU - Lustig, Shamir
AU - Attal-Singer, Joelle
AU - Cohen, Jonathan
PY - 2004/8
Y1 - 2004/8
N2 - Background & aims: Nutrition can interfere with organ function during the different stages of transplantation. Oral fish oil supplementation to kidney transplant recipients has been found to improve renal function. The aim of the present study was to determine the safety and tolerance of intravenous administration of fish-oil emulsion to heart-beating brain-dead donors and, subsequently, to the kidney recipients, and to assess its effects on renal function. Methods: A lipid emulsion enriched with omega-3 fatty acids (MLF 541) was given intravenously to 8 heart-beating, brain-dead organ donors for up to 4 h before organ harvesting and to the kidney recipients for 5 days postoperatively. Hemodynamic, biochemistry and hematological parameters were measured before and at the end of lipid administration in the donors and on posttransplantation days 1, 5, 30 and 180 in the recipients. Findings in the recipients were compared with a concurrent control group. Results: There were no significant changes in hemodynamic or laboratory parameters during the MLF infusion in the donors or the 5 days of MLF administration in the recipients. Blood urea nitrogen and serum creatinine levels decreased over time in both the study and control recipients (P<0.05 for both), with no significant between-group difference at any of the time points studied. Conclusions: Administration of MLF 541 is safe in organ donors and in kidney recipients. Further studies involving nutrients as pharmacological agents in organ transplantation are warranted.
AB - Background & aims: Nutrition can interfere with organ function during the different stages of transplantation. Oral fish oil supplementation to kidney transplant recipients has been found to improve renal function. The aim of the present study was to determine the safety and tolerance of intravenous administration of fish-oil emulsion to heart-beating brain-dead donors and, subsequently, to the kidney recipients, and to assess its effects on renal function. Methods: A lipid emulsion enriched with omega-3 fatty acids (MLF 541) was given intravenously to 8 heart-beating, brain-dead organ donors for up to 4 h before organ harvesting and to the kidney recipients for 5 days postoperatively. Hemodynamic, biochemistry and hematological parameters were measured before and at the end of lipid administration in the donors and on posttransplantation days 1, 5, 30 and 180 in the recipients. Findings in the recipients were compared with a concurrent control group. Results: There were no significant changes in hemodynamic or laboratory parameters during the MLF infusion in the donors or the 5 days of MLF administration in the recipients. Blood urea nitrogen and serum creatinine levels decreased over time in both the study and control recipients (P<0.05 for both), with no significant between-group difference at any of the time points studied. Conclusions: Administration of MLF 541 is safe in organ donors and in kidney recipients. Further studies involving nutrients as pharmacological agents in organ transplantation are warranted.
KW - Fish oil
KW - Kidney transplantation
KW - Organ donation
KW - Parenteral nutrition
UR - http://www.scopus.com/inward/record.url?scp=4243175925&partnerID=8YFLogxK
U2 - 10.1016/j.clnu.2003.10.007
DO - 10.1016/j.clnu.2003.10.007
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C2 - 15297096
AN - SCOPUS:4243175925
SN - 0261-5614
VL - 23
SP - 597
EP - 603
JO - Clinical Nutrition
JF - Clinical Nutrition
IS - 4
ER -