Renal damage following transplantations of heterologous placental tissue

V. Toder*, M. Blank, A. Fein, L. Nebel

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

Abstract

Immunological interrelations between placenta and kidney have become a matter of interest with regard to the pathogenesis of precclampsia. Kidney morphology of Lewis rats was studied following repeated transplantations of heterologous or syngeneic placental tissue. In most of the heterologous placenta-recipient animals, diffuse severe glomerular lesions were found, similar to those seen in women with preeclampsia. In the strongly responding recipients, endothelial cell swelling, narrowing of capillary lumina and proliferation of mesangial matrix were observed. Patchy areas of fluorescence associated with dense IgG deposition, as well as fibrin deposits demonstrated in the affected glomeruli, were correlated with histologic changes. The use of syngeneic placenta as a transplant did not cause histological or immunohistological changes. These findings support the view that differences in histocompatibility antigens between mother and fetus may be involved in the pathogenesis of the nephropathy in preeclampsia.

Original languageEnglish
Pages (from-to)21-28
Number of pages8
JournalGynecologic and Obstetric Investigation
Volume12
Issue number1
DOIs
StatePublished - 1981

Keywords

  • Histocompatibility complex
  • Kidney
  • Placenta
  • Preeclampsia

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