Removal of pathogenic autoantibodies by immunoadsorption

Alon Y. Hershko, Yaakov Naparstek

Research output: Contribution to journalArticlepeer-review

Abstract

Autoimmune diseases result from disrupted tolerance to self-antigens and subsequent damage to tissues and organs. In several diseases, specific autoantibodies have been either proved or suspected to play a role in this process. Consequently, several strategies have been devised in an attempt to discard the destructive immunoglobulins. Currently, both nonselective and epitope-specific methods are applied in several diseases. In this review, we provide a summary of the available data on elimination of pathogenic autoantibodies and discuss the advantages and pitfalls of the different approaches.

Original languageEnglish
Pages (from-to)635-646
Number of pages12
JournalAnnals of the New York Academy of Sciences
Volume1051
DOIs
StatePublished - 2005
Externally publishedYes

Keywords

  • Apheresis
  • Autoantibodies
  • Dilated cardiomyopathy
  • Immunoadsorption
  • Myasthenia gravis
  • Systemic lupus erythematosus

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