Removal of pathogenic autoantibodies by immunoadsorption

Alon Y. Hershko; Yaakov Naparstek

doi:10.1196/annals.1361.108

Removal of pathogenic autoantibodies by immunoadsorption

Alon Y. Hershko, Yaakov Naparstek

Research output: Contribution to journal › Article › peer-review

Abstract

Autoimmune diseases result from disrupted tolerance to self-antigens and subsequent damage to tissues and organs. In several diseases, specific autoantibodies have been either proved or suspected to play a role in this process. Consequently, several strategies have been devised in an attempt to discard the destructive immunoglobulins. Currently, both nonselective and epitope-specific methods are applied in several diseases. In this review, we provide a summary of the available data on elimination of pathogenic autoantibodies and discuss the advantages and pitfalls of the different approaches.

Original language	English
Pages (from-to)	635-646
Number of pages	12
Journal	Annals of the New York Academy of Sciences
Volume	1051
DOIs	https://doi.org/10.1196/annals.1361.108
State	Published - 2005
Externally published	Yes

Keywords

Apheresis
Autoantibodies
Dilated cardiomyopathy
Immunoadsorption
Myasthenia gravis
Systemic lupus erythematosus

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10.1196/annals.1361.108

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Removal of pathogenic autoantibodies by immunoadsorption

Abstract

Keywords

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